SRR663453
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.280
- MYC_TARGETS_V1+0.166
- UNFOLDED_PROTEIN_RESPONSE+0.161
- DNA_REPAIR+0.157
- MITOTIC_SPINDLE+0.092
- PI3K_AKT_MTOR_SIGNALING+0.063
- OXIDATIVE_PHOSPHORYLATION+0.057
- HEME_METABOLISM-0.007
- MYC_TARGETS_V2-0.013
- UV_RESPONSE_UP-0.050
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.552
- INFLAMMATORY_RESPONSE-0.496
- COAGULATION-0.485
- INTERFERON_GAMMA_RESPONSE-0.476
- ANGIOGENESIS-0.473
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.462
- TNFA_SIGNALING_VIA_NFKB-0.450
- IL6_JAK_STAT3_SIGNALING-0.447
- NOTCH_SIGNALING-0.437
- ALLOGRAFT_REJECTION-0.397
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1321244 | GTEX | — | 0.986 |
| 2 | SRR1351325 | GTEX | — | 0.986 |
| 3 | SRR1374246 | GTEX | — | 0.986 |
| 4 | SRR1343115 | GTEX | — | 0.984 |
| 5 | SRR1410934 | GTEX | — | 0.983 |
| 6 | SRR1406917 | GTEX | — | 0.982 |
| 7 | SRR1421140 | GTEX | — | 0.981 |
| 8 | SRR819999 | GTEX | — | 0.980 |
| 9 | SRR599225 | GTEX | — | 0.979 |
| 10 | SRR1429891 | GTEX | — | 0.979 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.280 | Remibrutinib | — uncovered |
| MYC_TARGETS_V1 | 0.166 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.161 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.157 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.092 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.063 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.057 | Remibrutinib | — uncovered |