Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0
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R22

51dfe633-c1b6-52df-b7da-0a0aa5bc184f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
91
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • CHOLESTEROL_HOMEOSTASIS+0.340
  • MYOGENESIS+0.230
  • WNT_BETA_CATENIN_SIGNALING+0.180
  • MYC_TARGETS_V2+0.170
  • UV_RESPONSE_UP+0.150
  • DNA_REPAIR+0.140
  • P53_PATHWAY+0.110
  • ESTROGEN_RESPONSE_EARLY+0.100
  • XENOBIOTIC_METABOLISM+0.100
  • APICAL_SURFACE+0.060

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.440
  • INTERFERON_GAMMA_RESPONSE-0.440
  • IL6_JAK_STAT3_SIGNALING-0.390
  • INTERFERON_ALPHA_RESPONSE-0.390
  • INFLAMMATORY_RESPONSE-0.360
  • PROTEIN_SECRETION-0.360
  • UV_RESPONSE_DN-0.360
  • COMPLEMENT-0.260
  • KRAS_SIGNALING_UP-0.260
  • PI3K_AKT_MTOR_SIGNALING-0.260

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1R45
bladder-landscape@3
0.840
2SJEPD037_D.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.821
3R100
bladder-landscape@3
0.805
4SRR25617832
breast-umap@18
B0.802
5TCGA-EW-A424-01A-11R-A24H-07
breast-umap@18
B0.787
6MNG857
mng-umap@100
0.786
74f521ce8-4aac-4ea5-abbe-732ff9ac5409
melanoma-umap@29
0.786
83e1c728a-cf38-4ca8-9d87-0bbf098567a6
melanoma-umap@29
0.784
9SRR25043618
head-neck@1
0.781
1085d43afd-9aac-48ca-a9c4-00357b7207e1
melanoma-umap@29
0.765