MNG857
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.505
- HEDGEHOG_SIGNALING+0.202
- WNT_BETA_CATENIN_SIGNALING+0.157
- APICAL_JUNCTION+0.130
- DNA_REPAIR+0.105
- KRAS_SIGNALING_DN+0.104
- NOTCH_SIGNALING+0.096
- CHOLESTEROL_HOMEOSTASIS+0.077
- MYOGENESIS+0.073
- APICAL_SURFACE+0.050
Top 10 suppressed
- INTERFERON_GAMMA_RESPONSE-0.467
- INTERFERON_ALPHA_RESPONSE-0.465
- PROTEIN_SECRETION-0.447
- ALLOGRAFT_REJECTION-0.415
- TNFA_SIGNALING_VIA_NFKB-0.401
- INFLAMMATORY_RESPONSE-0.384
- KRAS_SIGNALING_UP-0.377
- IL6_JAK_STAT3_SIGNALING-0.367
- ANGIOGENESIS-0.357
- ANDROGEN_RESPONSE-0.349
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1318407 | GTEX | — | 0.866 |
| 2 | MNG851 | — | — | 0.864 |
| 3 | SJEPD008_D.RNA-Seq | EPN | Posterior Fossa EPN | 0.861 |
| 4 | SRR2757338 | — | — | 0.854 |
| 5 | R63 | — | — | 0.852 |
| 6 | SRR1398992 | GTEX | — | 0.851 |
| 7 | SRR1474754 | GTEX | — | 0.847 |
| 8 | SRR1489054 | GTEX | — | 0.847 |
| 9 | MDT-AP-1120 | Med | Medulloblastoma | 0.843 |
| 10 | TCGA-AC-A6NO-01A-12R-A33J-07 | — | B | 0.843 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.505 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.202 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.157 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.130 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.105 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.104 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.096 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.077 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.073 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.050 | Temsirolimus | — uncovered |
| UV_RESPONSE_UP | 0.029 | Idelalisib | — uncovered |
| PEROXISOME | 0.014 | Idelalisib | — uncovered |