SRR1341277
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.432
- MYOGENESIS+0.307
- PANCREAS_BETA_CELLS+0.260
- HEDGEHOG_SIGNALING+0.226
- SPERMATOGENESIS+0.145
- ESTROGEN_RESPONSE_EARLY+0.142
- APICAL_JUNCTION+0.128
- ESTROGEN_RESPONSE_LATE+0.092
- UV_RESPONSE_DN+0.090
- COAGULATION+0.051
Top 10 suppressed
- MYC_TARGETS_V1-0.611
- INTERFERON_ALPHA_RESPONSE-0.531
- PROTEIN_SECRETION-0.510
- E2F_TARGETS-0.504
- INTERFERON_GAMMA_RESPONSE-0.491
- UNFOLDED_PROTEIN_RESPONSE-0.464
- G2M_CHECKPOINT-0.462
- IL6_JAK_STAT3_SIGNALING-0.426
- MTORC1_SIGNALING-0.402
- DNA_REPAIR-0.398
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1323043 | GTEX | — | 0.974 |
| 2 | SRR1431307 | GTEX | — | 0.969 |
| 3 | BS_MF47B9ZW | Ganglioglioma | — | 0.968 |
| 4 | SRR1331751 | GTEX | — | 0.967 |
| 5 | SRR1488672 | GTEX | — | 0.967 |
| 6 | SRR1392985 | GTEX | — | 0.966 |
| 7 | SRR1500868 | GTEX | — | 0.959 |
| 8 | SRR1480988 | GTEX | — | 0.958 |
| 9 | SRR1331335 | GTEX | — | 0.955 |
| 10 | SRR1315269 | GTEX | — | 0.955 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.432 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.307 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.260 | Cobimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.226 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.145 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.142 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.128 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.092 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.090 | Inavolisib | — uncovered |
| COAGULATION | 0.051 | Binimetinib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.045 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.032 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.029 | Temsirolimus | — uncovered |