SRR1392985
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.405
- PANCREAS_BETA_CELLS+0.337
- MYOGENESIS+0.326
- HEDGEHOG_SIGNALING+0.262
- APICAL_SURFACE+0.257
- SPERMATOGENESIS+0.205
- APICAL_JUNCTION+0.148
- ESTROGEN_RESPONSE_LATE+0.083
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.027
- ESTROGEN_RESPONSE_EARLY+0.015
Top 10 suppressed
- MYC_TARGETS_V1-0.546
- PROTEIN_SECRETION-0.502
- IL6_JAK_STAT3_SIGNALING-0.489
- INTERFERON_ALPHA_RESPONSE-0.483
- TGF_BETA_SIGNALING-0.465
- INTERFERON_GAMMA_RESPONSE-0.464
- E2F_TARGETS-0.451
- UNFOLDED_PROTEIN_RESPONSE-0.431
- G2M_CHECKPOINT-0.418
- TNFA_SIGNALING_VIA_NFKB-0.415
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1480988 | GTEX | — | 0.985 |
| 2 | SRR1439807 | GTEX | — | 0.980 |
| 3 | SRR1362532 | GTEX | — | 0.977 |
| 4 | SRR1466993 | GTEX | — | 0.971 |
| 5 | SRR1474951 | GTEX | — | 0.969 |
| 6 | SRR1320093 | GTEX | — | 0.968 |
| 7 | SRR1311794 | GTEX | — | 0.966 |
| 8 | SRR1341277 | GTEX | — | 0.966 |
| 9 | SRR1399028 | GTEX | — | 0.963 |
| 10 | SRR1335400 | GTEX | — | 0.962 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.405 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.337 | Cobimetinib | — uncovered |
| MYOGENESIS | 0.326 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.262 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.257 | Temsirolimus | — uncovered |
| SPERMATOGENESIS | 0.205 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.148 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.083 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.027 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.015 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.007 | Inavolisib | — uncovered |