MBCProject_6109_T1C_RNA
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MBCProject_6109_T1B_RNA | — | B | 0.969 |
| 2 | BS_K25F4J3V | ATRT | — | 0.923 |
| 3 | BS_N6N147BY | Embryonal tumors | — | 0.911 |
| 4 | C3L-04013 | — | cohortMD1 | 0.910 |
| 5 | TCGA-LA-A7SW-01A-11R-A405-07 | — | cohortSQ1 | 0.908 |
| 6 | TCGA-77-A5G6-01A-11R-A27Q-07 | — | cohortSQ1 | 0.904 |
| 7 | SRR12696755 | — | — | 0.904 |
| 8 | BS_HE57E1RP | medulloblastoma | — | 0.895 |
| 9 | b2e80b2b-559c-424e-837d-fa1de6b912e7 | — | — | 0.895 |
| 10 | SRR33346960 | — | — | 0.894 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V1 | 0.470 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.460 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.450 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.450 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.290 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.200 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.150 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.100 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.090 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.080 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.060 | Remibrutinib | — uncovered |
| APICAL_SURFACE | 0.040 | Temsirolimus | — uncovered |
| MTORC1_SIGNALING | 0.020 | Inavolisib | — uncovered |