Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-FD-A6TK-01A-42R-A33J-07

54ef6453-57d1-537d-880d-f3be05549b8b

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
10.84099869
os_event
false
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-50-6595-01A-12R-1858-07
lung-landscapes@6
cohortA10.933
2TCGA-E7-A97P-01A-11R-A38B-07
bladder-landscape@3
0.918
3SRR934864
brain-umap@2
0.917
4TCGA-XF-A9SY-01A-21R-A42T-07
bladder-landscape@3
0.915
5SRR934782
brain-umap@2
0.915
6SRR934753
brain-umap@2
0.914
7SRR934747
brain-umap@2
0.912
8TCGA-FD-A3B4-01A-12R-A206-07
bladder-landscape@3
0.910
9SRR934934
brain-umap@2
0.908
10C9EE359E-2F42-4D20-880D-FBF8B4953731
brain-umap@2
0.907

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 40 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.620Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.590Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.550Idelalisib— uncovered
ALLOGRAFT_REJECTION0.500Idelalisib— uncovered
TGF_BETA_SIGNALING0.490Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.440Inavolisib— uncovered
APICAL_JUNCTION0.430Inavolisib— uncovered
ANGIOGENESIS0.420Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.420Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.390Idelalisib— uncovered
ANDROGEN_RESPONSE0.370Inavolisib— uncovered
COMPLEMENT0.370Inavolisib— uncovered
MYC_TARGETS_V10.370Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.360Inavolisib— uncovered
G2M_CHECKPOINT0.350Inavolisib— uncovered
MITOTIC_SPINDLE0.350Inavolisib— uncovered
DNA_REPAIR0.310Idelalisib— uncovered
UV_RESPONSE_DN0.310Inavolisib— uncovered
E2F_TARGETS0.300Inavolisib— uncovered
MYC_TARGETS_V20.300Idelalisib— uncovered