MNG95
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR8613729 | — | E | 0.888 |
| 2 | SRR650180 | — | — | 0.887 |
| 3 | SRR8518323 | — | E | 0.872 |
| 4 | MNG171 | — | — | 0.866 |
| 5 | TCGA-58-A46M-01A-11R-A24H-07 | — | cohortSQ2 | 0.866 |
| 6 | SRR27320678 | — | — | 0.866 |
| 7 | SRR8518144 | — | E | 0.863 |
| 8 | TCGA-EW-A1PC-01B-11R-A21T-07 | — | C | 0.859 |
| 9 | C3N-00580 | — | cohortA1 | 0.859 |
| 10 | TCGA-66-2757-01A-01R-0851-07 | — | cohortMD1 | 0.856 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.663 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.630 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.540 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.517 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.430 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.414 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.351 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.339 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.329 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.270 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.263 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.194 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.058 | Remibrutinib | — uncovered |
| UV_RESPONSE_UP | 0.053 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.016 | Inavolisib | — uncovered |