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OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE

AML · Acute Myeloid Leukemia

58b4424b-7066-5e57-acc7-3da93d45e390

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
AML
cancer_type_detailed
Acute Myeloid Leukemia
subtype
cancer_type
AML
ccle_sample_id
OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
synthetic_from_ccle
true
display_name
OCI-AML2
ccle_lineage
blood
ccle_lineage_subtype
AML
ccle_lineage_sub_subtype
M4
oncotree_code
AML
cancer_type_detailed
Acute Myeloid Leukemia

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
ccle-aml@v2024.1
AML0.888
2KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
ccle-aml@v2024.1
AML0.886
3KASUMI6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
ccle-aml@v2024.1
AML0.862
4EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
ccle-aml@v2024.1
AML0.858
5PL21_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
ccle-aml@v2024.1
AML0.844
6TCGA-CR-6487-01A-11R-1873-07
head-neck@1
0.838
7MBCProject_1542_T2_RNA
breast-umap@18
D0.830
8NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
ccle-aml@v2024.1
AML0.821
9SRR8518222
breast-umap@18
D0.806
10HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
ccle-aml@v2024.1
AML0.798

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 15 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.764Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.405Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.360Inavolisib— uncovered
E2F_TARGETS0.270Inavolisib— uncovered
COMPLEMENT0.250Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.222Idelalisib— uncovered
G2M_CHECKPOINT0.174Inavolisib— uncovered
KRAS_SIGNALING_UP0.116Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.066Inavolisib— uncovered
DNA_REPAIR0.052Idelalisib— uncovered
MYC_TARGETS_V10.052Inavolisib— uncovered
SPERMATOGENESIS0.037Inavolisib— uncovered
IL2_STAT5_SIGNALING0.025Idelalisib— uncovered
HEME_METABOLISM0.008Temsirolimus— uncovered
PI3K_AKT_MTOR_SIGNALING0.004Inavolisib— uncovered