MBCProject_1542_T2_RNA

— · D

d2f9f2c4-9b5e-5e5b-ba06-d6d6282c7257

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: D
subtype: D

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR8518222 breast-umap@18	—	D	0.915
2	TCGA-CR-6487-01A-11R-1873-07 head-neck@1	—	—	0.910
3	SRR1313144 breast-umap@18	—	D	0.886
4	BSR_11_0107_E3_S77 breast-umap@18	—	D	0.879
5	SRR33532827 breast-umap@18	—	D	0.876
6	MBCProject_0454_T1_RNA breast-umap@18	—	B	0.868
7	SRR25043627 head-neck@1	—	—	0.867
8	SRR6013594 lung-landscapes@6	—	cohortMD2	0.855
9	C3N-00497 lung-landscapes@6	—	cohortSQ1	0.854
10	C3N-04382 lung-landscapes@6	—	cohortMD1	0.854

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 17 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
ALLOGRAFT_REJECTION	0.520	Idelalisib	— uncovered
E2F_TARGETS	0.480	Inavolisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.440	Idelalisib	— uncovered
G2M_CHECKPOINT	0.400	Inavolisib	— uncovered
MYC_TARGETS_V1	0.390	Inavolisib	— uncovered
INTERFERON_ALPHA_RESPONSE	0.380	Inavolisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.260	Inavolisib	— uncovered
OXIDATIVE_PHOSPHORYLATION	0.120	Remibrutinib	— uncovered
COMPLEMENT	0.110	Inavolisib	— uncovered
DNA_REPAIR	0.100	Idelalisib	— uncovered
PI3K_AKT_MTOR_SIGNALING	0.090	Inavolisib	— uncovered
INFLAMMATORY_RESPONSE	0.080	Idelalisib	— uncovered
SPERMATOGENESIS	0.050	Inavolisib	— uncovered
IL2_STAT5_SIGNALING	0.040	Idelalisib	— uncovered
APOPTOSIS	0.010	Idelalisib	— uncovered
KRAS_SIGNALING_UP	0.010	Inavolisib	— uncovered
MTORC1_SIGNALING	0.010	Inavolisib	— uncovered