dfc53815-0784-48c7-84aa-f23d087a13df
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.600
- MYC_TARGETS_V1+0.400
- OXIDATIVE_PHOSPHORYLATION+0.400
- DNA_REPAIR+0.200
- PROTEIN_SECRETION+0.200
- E2F_TARGETS+0.100
- FATTY_ACID_METABOLISM+0.100
- G2M_CHECKPOINT+0.100
- PANCREAS_BETA_CELLS+0.100
- UNFOLDED_PROTEIN_RESPONSE+0.100
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.500
- INFLAMMATORY_RESPONSE-0.500
- ALLOGRAFT_REJECTION-0.400
- APICAL_SURFACE-0.400
- COMPLEMENT-0.400
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- IL2_STAT5_SIGNALING-0.400
- INTERFERON_ALPHA_RESPONSE-0.400
- INTERFERON_GAMMA_RESPONSE-0.400
- KRAS_SIGNALING_UP-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | R16 | — | — | 0.911 |
| 2 | 15d39440-6bb8-4ecb-add1-9ae8b007dc70 | — | — | 0.905 |
| 3 | SRR5088890 | — | — | 0.891 |
| 4 | SRR5088895 | — | — | 0.887 |
| 5 | SRR2780123 | — | — | 0.887 |
| 6 | BS_HKZENFDA | medulloblastoma | — | 0.886 |
| 7 | s0112303 | — | — | 0.885 |
| 8 | BS_1HQ76V6D | Embryonal tumors | — | 0.885 |
| 9 | SRR5088889 | — | — | 0.884 |
| 10 | 20110070.TNBC | — | E | 0.882 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.600 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.400 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.400 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.200 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.200 | Remibrutinib | — uncovered |
| E2F_TARGETS | 0.100 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.100 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.100 | Cobimetinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.100 | Idelalisib | — uncovered |