Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · lung-landscapes@6

f54ad6e1.b983.4270.8925.848d56f2d461

— · cohortMD2

5af5b413-22ed-556d-afa9-6db81f2bcc01

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
cohortMD2
subtype
cohortMD2
age_years
59

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1X6e4edcae.68aa.4e0a.80bc.d8114f132bba
lung-landscapes@6
—cohortMD20.925
2SRR8518396
breast-umap@18
—A0.903
3SRR5088906
melanoma-umap@29
——0.901
4SAMN03290935
melanoma-umap@29
——0.894
5SRR8518419
breast-umap@18
—A0.889
6C3L-00095
lung-landscapes@6
—cohortMD20.886
7SRR8526727
lung-landscapes@6
—cohortMD20.876
8SRR2016962
head-neck@1
——0.876
9C3N-00738
lung-landscapes@6
—cohortMD20.869
10ERR2208941
melanoma-umap@29
——0.867

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.560Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.520Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.520Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.470Idelalisib— uncovered
ALLOGRAFT_REJECTION0.460Idelalisib— uncovered
COAGULATION0.450Binimetinib— uncovered
ANGIOGENESIS0.440Remibrutinib— uncovered
COMPLEMENT0.400Inavolisib— uncovered
IL2_STAT5_SIGNALING0.400Idelalisib— uncovered
PANCREAS_BETA_CELLS0.360Cobimetinib— uncovered
HYPOXIA0.350Idelalisib— uncovered
KRAS_SIGNALING_UP0.350Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.350Inavolisib— uncovered
MYOGENESIS0.340Inavolisib— uncovered
APOPTOSIS0.310Idelalisib— uncovered
UV_RESPONSE_DN0.310Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.290Idelalisib— uncovered
P53_PATHWAY0.280Idelalisib— uncovered
ANDROGEN_RESPONSE0.260Inavolisib— uncovered
TGF_BETA_SIGNALING0.250Inavolisib— uncovered