Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG1104

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5bc3cb17-24de-52d7-aeae-b77d63be6c66

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • TGF_BETA_SIGNALING+0.493
  • PROTEIN_SECRETION+0.400
  • MITOTIC_SPINDLE+0.357
  • NOTCH_SIGNALING+0.332
  • UV_RESPONSE_DN+0.268
  • CHOLESTEROL_HOMEOSTASIS+0.252
  • PEROXISOME+0.248
  • APOPTOSIS+0.246
  • HEME_METABOLISM+0.240
  • ESTROGEN_RESPONSE_EARLY+0.238

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.407
  • OXIDATIVE_PHOSPHORYLATION-0.338
  • PANCREAS_BETA_CELLS-0.337
  • INFLAMMATORY_RESPONSE-0.235
  • IL6_JAK_STAT3_SIGNALING-0.209
  • INTERFERON_GAMMA_RESPONSE-0.206
  • MYC_TARGETS_V2-0.179
  • MYC_TARGETS_V1-0.150
  • ANGIOGENESIS-0.125
  • KRAS_SIGNALING_DN-0.110

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG683
mng-umap@100
——0.774
2MNG1193
mng-umap@100
——0.769
3MNG1026
mng-umap@100
——0.764
4MNG1051
mng-umap@100
——0.764
5MNG1062
mng-umap@100
——0.730
6C138638F-C6CB-439B-BFF0-CF097E0B421E
brain-umap@2
——0.722
7SRR934850
brain-umap@2
——0.715
8MNG993
mng-umap@100
——0.704
9MNG127
mng-umap@100
——0.703
10MNG1024
mng-umap@100
——0.703

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 35 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
TGF_BETA_SIGNALING0.493Inavolisib— uncovered
PROTEIN_SECRETION0.400Remibrutinib— uncovered
MITOTIC_SPINDLE0.357Inavolisib— uncovered
NOTCH_SIGNALING0.332Inavolisib— uncovered
UV_RESPONSE_DN0.268Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.252Remibrutinib— uncovered
PEROXISOME0.248Idelalisib— uncovered
APOPTOSIS0.246Idelalisib— uncovered
HEME_METABOLISM0.240Temsirolimus— uncovered
ESTROGEN_RESPONSE_EARLY0.238Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.230Inavolisib— uncovered
APICAL_JUNCTION0.229Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.207Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.195Idelalisib— uncovered
APICAL_SURFACE0.187Temsirolimus— uncovered
BILE_ACID_METABOLISM0.176Inavolisib— uncovered
DNA_REPAIR0.151Idelalisib— uncovered
ADIPOGENESIS0.140Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.124Inavolisib— uncovered
ANDROGEN_RESPONSE0.121Inavolisib— uncovered