MNG1026
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.399
- PEROXISOME+0.299
- BILE_ACID_METABOLISM+0.284
- UV_RESPONSE_DN+0.242
- CHOLESTEROL_HOMEOSTASIS+0.232
- NOTCH_SIGNALING+0.228
- ANDROGEN_RESPONSE+0.208
- HEME_METABOLISM+0.200
- TGF_BETA_SIGNALING+0.198
- UNFOLDED_PROTEIN_RESPONSE+0.190
Top 10 suppressed
- MYC_TARGETS_V2-0.294
- ALLOGRAFT_REJECTION-0.279
- OXIDATIVE_PHOSPHORYLATION-0.269
- PANCREAS_BETA_CELLS-0.210
- INTERFERON_ALPHA_RESPONSE-0.191
- INTERFERON_GAMMA_RESPONSE-0.150
- IL6_JAK_STAT3_SIGNALING-0.129
- INFLAMMATORY_RESPONSE-0.124
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.121
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.120
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG683 | — | — | 0.783 |
| 2 | MNG1071 | — | — | 0.782 |
| 3 | MNG1193 | — | — | 0.778 |
| 4 | MNG1104 | — | — | 0.764 |
| 5 | TCGA-D8-A1X7-01A-11R-A14M-07 | — | B | 0.744 |
| 6 | SRR15069611 | — | — | 0.740 |
| 7 | C138638F-C6CB-439B-BFF0-CF097E0B421E | — | — | 0.726 |
| 8 | MNG993 | — | — | 0.715 |
| 9 | MNG1056 | — | — | 0.707 |
| 10 | TCGA-A1-A0SJ-01A-11R-A084-07 | — | B | 0.704 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 32 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.399 | Remibrutinib | — uncovered |
| PEROXISOME | 0.299 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.284 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.242 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.232 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.228 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.208 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.200 | Temsirolimus | — uncovered |
| TGF_BETA_SIGNALING | 0.198 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.190 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.188 | Idelalisib | — uncovered |
| MTORC1_SIGNALING | 0.182 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.181 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.179 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.163 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.131 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.123 | Remibrutinib | — uncovered |
| APICAL_JUNCTION | 0.103 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.101 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.100 | Inavolisib | — uncovered |