SRR1474951
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.404
- PANCREAS_BETA_CELLS+0.331
- SPERMATOGENESIS+0.323
- HEDGEHOG_SIGNALING+0.274
- MYOGENESIS+0.201
- UV_RESPONSE_DN+0.171
- APICAL_SURFACE+0.084
- APICAL_JUNCTION+0.010
- ESTROGEN_RESPONSE_LATE+0.007
- OXIDATIVE_PHOSPHORYLATION+0.004
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.554
- MYC_TARGETS_V1-0.527
- INTERFERON_GAMMA_RESPONSE-0.513
- TNFA_SIGNALING_VIA_NFKB-0.504
- INTERFERON_ALPHA_RESPONSE-0.495
- E2F_TARGETS-0.446
- INFLAMMATORY_RESPONSE-0.439
- ALLOGRAFT_REJECTION-0.428
- TGF_BETA_SIGNALING-0.421
- APOPTOSIS-0.418
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1362532 | GTEX | — | 0.982 |
| 2 | SRR1334564 | GTEX | — | 0.979 |
| 3 | SRR1459441 | GTEX | — | 0.977 |
| 4 | SRR1466993 | GTEX | — | 0.976 |
| 5 | SRR1353176 | GTEX | — | 0.975 |
| 6 | SRR1320093 | GTEX | — | 0.974 |
| 7 | SRR1331335 | GTEX | — | 0.971 |
| 8 | SRR1480988 | GTEX | — | 0.970 |
| 9 | SRR1392985 | GTEX | — | 0.969 |
| 10 | SRR1310008 | GTEX | — | 0.969 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.404 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.331 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.323 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.274 | Inavolisib | — uncovered |
| MYOGENESIS | 0.201 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.171 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.084 | Temsirolimus | — uncovered |
| APICAL_JUNCTION | 0.010 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.007 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.004 | Remibrutinib | — uncovered |