9ff8aa32-18fe-439b-a83c-e39282bd3421
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 73.2731006160164
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYOGENESIS+0.320
- WNT_BETA_CATENIN_SIGNALING+0.260
- NOTCH_SIGNALING+0.250
- SPERMATOGENESIS+0.080
- HEDGEHOG_SIGNALING+0.070
- TGF_BETA_SIGNALING+0.060
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.030
- KRAS_SIGNALING_DN+0.020
- APICAL_JUNCTION-0.040
- FATTY_ACID_METABOLISM-0.040
Top 10 suppressed
- MYC_TARGETS_V2-0.520
- ALLOGRAFT_REJECTION-0.480
- MTORC1_SIGNALING-0.460
- INFLAMMATORY_RESPONSE-0.450
- IL6_JAK_STAT3_SIGNALING-0.430
- MYC_TARGETS_V1-0.420
- UNFOLDED_PROTEIN_RESPONSE-0.420
- COMPLEMENT-0.360
- TNFA_SIGNALING_VIA_NFKB-0.360
- CHOLESTEROL_HOMEOSTASIS-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR25617883 | — | B | 0.867 |
| 2 | SRR1516067 | — | — | 0.865 |
| 3 | SRR6013544 | — | cohortA1 | 0.865 |
| 4 | SRR1442885 | GTEX | — | 0.862 |
| 5 | MDT-AP-0393 | Med | Medulloblastoma | 0.861 |
| 6 | C3N-00293 | — | cohortA1 | 0.860 |
| 7 | s0102877 | — | — | 0.853 |
| 8 | df6cc1d8-c28f-4530-95ff-4e18ee383e88 | — | — | 0.850 |
| 9 | AUR-AFE5-TTM9-A-1-1-R-A742-41 | — | D | 0.847 |
| 10 | C3N-03420 | — | cohortA1 | 0.845 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYOGENESIS | 0.320 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.260 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.250 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.080 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.070 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.060 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.030 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.020 | Remibrutinib | — uncovered |