SRR1442885
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.327
- MYOGENESIS+0.266
- BILE_ACID_METABOLISM+0.131
- SPERMATOGENESIS+0.093
- HEDGEHOG_SIGNALING+0.066
- ESTROGEN_RESPONSE_LATE-0.010
- HEME_METABOLISM-0.036
- UV_RESPONSE_DN-0.060
- ESTROGEN_RESPONSE_EARLY-0.075
- FATTY_ACID_METABOLISM-0.075
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.552
- MYC_TARGETS_V1-0.546
- MTORC1_SIGNALING-0.516
- TNFA_SIGNALING_VIA_NFKB-0.483
- E2F_TARGETS-0.473
- G2M_CHECKPOINT-0.468
- UNFOLDED_PROTEIN_RESPONSE-0.451
- INFLAMMATORY_RESPONSE-0.441
- INTERFERON_GAMMA_RESPONSE-0.441
- INTERFERON_ALPHA_RESPONSE-0.421
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR821581 | GTEX | — | 0.950 |
| 2 | SRR1414833 | GTEX | — | 0.945 |
| 3 | SRR1432343 | GTEX | — | 0.945 |
| 4 | SRR1466850 | GTEX | — | 0.944 |
| 5 | SRR1070986 | GTEX | — | 0.938 |
| 6 | SRR1477634 | GTEX | — | 0.938 |
| 7 | SRR1325986 | GTEX | — | 0.938 |
| 8 | SRR1404640 | GTEX | — | 0.937 |
| 9 | SRR1359388 | GTEX | — | 0.936 |
| 10 | SRR1406561 | GTEX | — | 0.934 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.327 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.266 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.131 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.093 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.066 | Inavolisib | — uncovered |