Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_1RXZ3BP7

low-grade glioma

6317a311-fc35-5fb7-946a-f95fca332b89

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
low-grade glioma
cancer_type_detailed
subtype
cancer_type
low-grade glioma
overall_survival_months
96.81340341655715
age_years
6.09
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_ZV9Z3SY6
brain-umap@2
pilocytic astrocytoma0.954
2MDT-AP-2869
medullo-epn-umap@date-based
MedMedulloblastoma0.950
3SRR1797296
lung-landscapes@6
cohortMD20.944
4TCGA-22-1000-01A-01R-A32Z-07
lung-landscapes@6
cohortSQ10.937
5MDT-AP-0384
medullo-epn-umap@date-based
MedMedulloblastoma0.937
6SRR5088824
melanoma-umap@29
0.936
7ERR2598314
medullo-epn-umap@date-based
fetalfetal0.936
8SRR5088860
melanoma-umap@29
0.930
9MDT-AP-3277
medullo-epn-umap@date-based
MedMedulloblastoma0.930
10TCGA-A2-A0EN-01A-13R-A084-07
breast-umap@18
A0.930

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 33 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
IL6_JAK_STAT3_SIGNALING0.575Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.561Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.548Idelalisib— uncovered
ANGIOGENESIS0.545Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.514Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.501Inavolisib— uncovered
ALLOGRAFT_REJECTION0.497Idelalisib— uncovered
COMPLEMENT0.465Inavolisib— uncovered
COAGULATION0.463Binimetinib— uncovered
KRAS_SIGNALING_UP0.433Inavolisib— uncovered
TGF_BETA_SIGNALING0.395Inavolisib— uncovered
IL2_STAT5_SIGNALING0.379Idelalisib— uncovered
HEDGEHOG_SIGNALING0.376Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.373Inavolisib— uncovered
MYOGENESIS0.367Inavolisib— uncovered
P53_PATHWAY0.269Idelalisib— uncovered
APICAL_SURFACE0.263Temsirolimus— uncovered
HYPOXIA0.257Idelalisib— uncovered
NOTCH_SIGNALING0.256Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.244Inavolisib— uncovered