Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · bladder-landscape@3

TCGA-UY-A78K-01A-11R-A33J-07

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654946bd-4eb8-592f-b99f-69a6a02315cf

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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overall_survival_months
17.60840999
os_event
true
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ALLOGRAFT_REJECTION+0.400
  • E2F_TARGETS+0.400
  • DNA_REPAIR+0.360
  • OXIDATIVE_PHOSPHORYLATION+0.330
  • G2M_CHECKPOINT+0.290
  • SPERMATOGENESIS+0.290
  • INTERFERON_GAMMA_RESPONSE+0.270
  • ADIPOGENESIS+0.240
  • FATTY_ACID_METABOLISM+0.230
  • INTERFERON_ALPHA_RESPONSE+0.230

Top 10 suppressed

  • TGF_BETA_SIGNALING-0.390
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.380
  • WNT_BETA_CATENIN_SIGNALING-0.370
  • ANGIOGENESIS-0.340
  • HYPOXIA-0.330
  • P53_PATHWAY-0.280
  • TNFA_SIGNALING_VIA_NFKB-0.280
  • UV_RESPONSE_DN-0.240
  • APICAL_JUNCTION-0.200
  • HEDGEHOG_SIGNALING-0.190

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1313162
breast-umap@18
—C0.823
2SRR26320066
bladder-landscape@3
——0.821
3TCGA-CV-6433-01A-11R-1686-07
head-neck@1
——0.813
4TCGA-KU-A6H7-01A-11R-A31N-07
head-neck@1
——0.789
5SRR12202422
bladder-landscape@3
——0.786
6SRR12202423
bladder-landscape@3
——0.780
7TCGA-AR-A0TV-01A-21R-A084-07
breast-umap@18
—B0.778
8C3N-00579
lung-landscapes@6
—cohortA10.774
9SRR4296112
lung-landscapes@6
—cohortA10.772
10TCGA-73-7499-01A-11R-2187-07
lung-landscapes@6
—cohortA10.769

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.400Idelalisib— uncovered
E2F_TARGETS0.400Inavolisib— uncovered
DNA_REPAIR0.360Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.330Remibrutinib— uncovered
G2M_CHECKPOINT0.290Inavolisib— uncovered
SPERMATOGENESIS0.290Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.270Idelalisib— uncovered
ADIPOGENESIS0.240Inavolisib— uncovered
FATTY_ACID_METABOLISM0.230Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.230Inavolisib— uncovered
MYC_TARGETS_V10.210Inavolisib— uncovered
BILE_ACID_METABOLISM0.200Inavolisib— uncovered
PEROXISOME0.200Idelalisib— uncovered
IL2_STAT5_SIGNALING0.160Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.140Inavolisib— uncovered
MITOTIC_SPINDLE0.140Inavolisib— uncovered
PANCREAS_BETA_CELLS0.140Cobimetinib— uncovered
XENOBIOTIC_METABOLISM0.140Inavolisib— uncovered
COMPLEMENT0.120Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.120Inavolisib— uncovered