MBCProject_0454_T1_RNA
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.610
- INTERFERON_GAMMA_RESPONSE+0.470
- E2F_TARGETS+0.450
- ALLOGRAFT_REJECTION+0.430
- MYC_TARGETS_V1+0.430
- G2M_CHECKPOINT+0.380
- MYC_TARGETS_V2+0.370
- PI3K_AKT_MTOR_SIGNALING+0.270
- UNFOLDED_PROTEIN_RESPONSE+0.270
- DNA_REPAIR+0.260
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.630
- HEDGEHOG_SIGNALING-0.480
- HYPOXIA-0.480
- ANGIOGENESIS-0.460
- MYOGENESIS-0.460
- TGF_BETA_SIGNALING-0.450
- COAGULATION-0.430
- NOTCH_SIGNALING-0.430
- UV_RESPONSE_DN-0.430
- FATTY_ACID_METABOLISM-0.410
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR11296816 | — | — | 0.925 |
| 2 | MBCProject_1819_T1_RNA | — | C | 0.874 |
| 3 | C3N-04382 | — | cohortMD1 | 0.871 |
| 4 | MBCProject_1542_T2_RNA | — | D | 0.868 |
| 5 | 1b0a23c2-785d-4a14-b673-86c97ceff401 | — | — | 0.857 |
| 6 | s0112318 | — | — | 0.854 |
| 7 | SRR10900596 | — | — | 0.852 |
| 8 | MBCProject_3717_T1_RNA | — | B | 0.851 |
| 9 | SRR8518222 | — | D | 0.839 |
| 10 | TCGA-AR-A24H-01A-11R-A169-07 | — | B | 0.837 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.610 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.470 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.450 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.430 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.430 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.380 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.370 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.270 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.270 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.260 | Idelalisib | — uncovered |
| MTORC1_SIGNALING | 0.110 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.110 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.010 | Idelalisib | — uncovered |