TCGA-CR-7370-01A-11R-2132-07
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.280
- WNT_BETA_CATENIN_SIGNALING+0.280
- G2M_CHECKPOINT+0.270
- MITOTIC_SPINDLE+0.270
- UV_RESPONSE_DN+0.260
- E2F_TARGETS+0.220
- NOTCH_SIGNALING+0.110
- TGF_BETA_SIGNALING+0.050
- PROTEIN_SECRETION+0.000
- SPERMATOGENESIS-0.010
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.480
- TNFA_SIGNALING_VIA_NFKB-0.410
- OXIDATIVE_PHOSPHORYLATION-0.400
- ALLOGRAFT_REJECTION-0.390
- INTERFERON_GAMMA_RESPONSE-0.390
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.360
- INFLAMMATORY_RESPONSE-0.330
- MYOGENESIS-0.330
- COAGULATION-0.280
- HYPOXIA-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-AC-A2QH-01B-04R-A22O-07 | — | D | 0.905 |
| 2 | SJEPD031175_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.890 |
| 3 | s0122214 | — | — | 0.888 |
| 4 | SRR10899974 | — | — | 0.880 |
| 5 | SJEPD030911_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.869 |
| 6 | MDT-AP-2885 | Med | Medulloblastoma | 0.866 |
| 7 | MDT-AP-3325 | Med | Medulloblastoma | 0.863 |
| 8 | TCGA-56-8083-01A-11R-2247-07 | — | cohortMD1 | 0.860 |
| 9 | MNG335 | — | — | 0.856 |
| 10 | SRR6013547 | — | cohortMD1 | 0.852 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.280 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.280 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.270 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.270 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.260 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.220 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.110 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.050 | Inavolisib | — uncovered |