s0122214
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.400
- MITOTIC_SPINDLE+0.400
- E2F_TARGETS+0.300
- PANCREAS_BETA_CELLS+0.300
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.200
- HEDGEHOG_SIGNALING+0.200
- SPERMATOGENESIS+0.200
- UV_RESPONSE_DN+0.200
- WNT_BETA_CATENIN_SIGNALING+0.200
- ANGIOGENESIS+0.100
Top 10 suppressed
- INTERFERON_GAMMA_RESPONSE-0.600
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.600
- ALLOGRAFT_REJECTION-0.500
- INFLAMMATORY_RESPONSE-0.500
- INTERFERON_ALPHA_RESPONSE-0.500
- OXIDATIVE_PHOSPHORYLATION-0.500
- ADIPOGENESIS-0.400
- APICAL_SURFACE-0.400
- CHOLESTEROL_HOMEOSTASIS-0.400
- COMPLEMENT-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR2932838 | — | — | 0.933 |
| 2 | TCGA-AC-A2QH-01B-04R-A22O-07 | — | D | 0.931 |
| 3 | ERR2208889 | — | — | 0.909 |
| 4 | TCGA-63-A5MW-01A-11R-A26W-07 | — | cohortMD1 | 0.896 |
| 5 | 0918cbd5-edd0-41c8-8b67-677f35ad4611 | — | — | 0.891 |
| 6 | TCGA-CR-7370-01A-11R-2132-07 | — | — | 0.888 |
| 7 | SRR10899974 | — | — | 0.878 |
| 8 | b0be4742-ccb7-48e2-b756-0c384321114e | — | — | 0.876 |
| 9 | ERR2208903 | — | — | 0.875 |
| 10 | SRR6013547 | — | cohortMD1 | 0.869 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.400 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.400 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.300 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.300 | Cobimetinib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.200 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.200 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.200 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.200 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.200 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.100 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.100 | Inavolisib | — uncovered |