Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG151

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6bc0e520-32d1-5758-964c-ce7549cf4429

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • E2F_TARGETS+0.524
  • MYC_TARGETS_V2+0.505
  • G2M_CHECKPOINT+0.502
  • TNFA_SIGNALING_VIA_NFKB+0.399
  • MTORC1_SIGNALING+0.382
  • UNFOLDED_PROTEIN_RESPONSE+0.375
  • UV_RESPONSE_UP+0.316
  • GLYCOLYSIS+0.299
  • MYC_TARGETS_V1+0.294
  • HYPOXIA+0.279

Top 10 suppressed

  • UV_RESPONSE_DN-0.250
  • ANDROGEN_RESPONSE-0.227
  • MYOGENESIS-0.191
  • APICAL_SURFACE-0.186
  • HEME_METABOLISM-0.152
  • PROTEIN_SECRETION-0.130
  • XENOBIOTIC_METABOLISM-0.126
  • PANCREAS_BETA_CELLS-0.121
  • FATTY_ACID_METABOLISM-0.120
  • INTERFERON_ALPHA_RESPONSE-0.114

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BD887C3F-0002-4EC8-B845-9B38E78A3906
brain-umap@2
——0.829
2TCGA-A2-A0D2-01A-21R-A034-07
breast-umap@18
—E0.807
3MNG988
mng-umap@100
——0.805
4E24D233D-71BD-4EC2-A671-375917F24E5C
brain-umap@2
——0.803
5D1729A17-148B-4C58-BEB5-7C4349A0E920
brain-umap@2
——0.798
6109ABE6B-033D-47E8-A03A-D285BE82C17B
brain-umap@2
——0.797
7GSM6454736
breast-umap@18
—E0.796
850DE1FDE-B85E-4677-B0F8-08275DA41A6E
brain-umap@2
——0.787
95E729BD1-654D-4334-A80F-3EDD472551B4
brain-umap@2
——0.786
10BS_23QW0BBA
brain-umap@2
high-grade glioma—0.784

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 34 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.524Inavolisib— uncovered
MYC_TARGETS_V20.505Idelalisib— uncovered
G2M_CHECKPOINT0.502Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.399Inavolisib— uncovered
MTORC1_SIGNALING0.382Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.375Idelalisib— uncovered
UV_RESPONSE_UP0.316Idelalisib— uncovered
GLYCOLYSIS0.299Inavolisib— uncovered
MYC_TARGETS_V10.294Inavolisib— uncovered
HYPOXIA0.279Idelalisib— uncovered
DNA_REPAIR0.260Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.257Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.254Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.207Inavolisib— uncovered
APOPTOSIS0.195Idelalisib— uncovered
NOTCH_SIGNALING0.191Inavolisib— uncovered
P53_PATHWAY0.184Idelalisib— uncovered
MITOTIC_SPINDLE0.178Inavolisib— uncovered
ALLOGRAFT_REJECTION0.159Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.154Inavolisib— uncovered