Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · medullo-epn-umap@date-based

MDT-AP-2902

Med · Medulloblastoma

6f0fe32a-5ac8-50cb-a70a-b78c5c08f3c1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Med
cancer_type_detailed
—
subtype
Medulloblastoma
cancer_type
Med
subtype
Medulloblastoma
new_clusters
S1
umap1_2d
-0.974604948
umap2_2d
-11.08867886
umap1_3d
-2.827082508
umap2_3d
-0.21830391
umap3_3d
5.888494934
dataset
Med-Taylor

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • IL6_JAK_STAT3_SIGNALING+0.420
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.400
  • ALLOGRAFT_REJECTION+0.390
  • COAGULATION+0.380
  • INFLAMMATORY_RESPONSE+0.380
  • INTERFERON_GAMMA_RESPONSE+0.360
  • COMPLEMENT+0.350
  • KRAS_SIGNALING_UP+0.350
  • INTERFERON_ALPHA_RESPONSE+0.330
  • PANCREAS_BETA_CELLS+0.330

Top 10 suppressed

  • OXIDATIVE_PHOSPHORYLATION-0.190
  • DNA_REPAIR-0.160
  • HEME_METABOLISM-0.140
  • MYC_TARGETS_V2-0.130
  • SPERMATOGENESIS-0.130
  • WNT_BETA_CATENIN_SIGNALING-0.110
  • MITOTIC_SPINDLE-0.080
  • PI3K_AKT_MTOR_SIGNALING-0.030
  • FATTY_ACID_METABOLISM+0.030
  • HEDGEHOG_SIGNALING+0.030

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MDT-AP-2910
medullo-epn-umap@date-based
MedMedulloblastoma0.894
2MDT-AP-0815
medullo-epn-umap@date-based
MedMedulloblastoma0.888
3BS_J1AB8PMA
medullo-epn-umap@date-based
MedMedulloblastoma0.881
4MDT-AP-2377
medullo-epn-umap@date-based
MedMedulloblastoma0.871
5MDT-AP-3095
medullo-epn-umap@date-based
MedMedulloblastoma0.868
6MNG639
mng-umap@100
——0.860
7MDT-AP-2167
medullo-epn-umap@date-based
MedMedulloblastoma0.859
8DRR168605
bladder-landscape@3
——0.858
9SRR1797276
lung-landscapes@6
—cohortMD20.857
10MDT-AP-2990
medullo-epn-umap@date-based
MedMedulloblastoma0.850

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 42 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
IL6_JAK_STAT3_SIGNALING0.420Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.400Inavolisib— uncovered
ALLOGRAFT_REJECTION0.390Idelalisib— uncovered
COAGULATION0.380Binimetinib— uncovered
INFLAMMATORY_RESPONSE0.380Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.360Idelalisib— uncovered
COMPLEMENT0.350Inavolisib— uncovered
KRAS_SIGNALING_UP0.350Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.330Inavolisib— uncovered
PANCREAS_BETA_CELLS0.330Cobimetinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.310Inavolisib— uncovered
ANDROGEN_RESPONSE0.290Inavolisib— uncovered
MYC_TARGETS_V10.270Inavolisib— uncovered
APOPTOSIS0.260Idelalisib— uncovered
IL2_STAT5_SIGNALING0.260Idelalisib— uncovered
UV_RESPONSE_DN0.230Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.220Inavolisib— uncovered
E2F_TARGETS0.190Inavolisib— uncovered
BILE_ACID_METABOLISM0.170Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.170Idelalisib— uncovered