MNG662
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | cf37eb41-0595-4a82-a65b-3058902a48d4 | — | — | 0.857 |
| 2 | ERR2208933 | — | — | 0.837 |
| 3 | SRR25043617 | — | — | 0.835 |
| 4 | SRR4195654 | — | — | 0.835 |
| 5 | 530f723a-ac5b-4e14-93b9-1d501b92fddd | — | — | 0.833 |
| 6 | TCGA-85-8352-01A-31R-2326-07 | — | cohortMD1 | 0.831 |
| 7 | BS_53M8PP88 | EPN | EPN Tumor | 0.828 |
| 8 | SJEPD001539_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.823 |
| 9 | TCGA-GV-A40G-01A-11R-A23N-07 | — | — | 0.822 |
| 10 | TCGA-B6-A0IB-01A-11R-A034-07 | — | B | 0.821 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 21 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.381 | Idelalisib | — uncovered |
| PEROXISOME | 0.322 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.318 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.188 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.167 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.142 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.133 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.132 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.126 | Temsirolimus | — uncovered |
| PANCREAS_BETA_CELLS | 0.111 | Cobimetinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.110 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.108 | Remibrutinib | — uncovered |
| G2M_CHECKPOINT | 0.087 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.078 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.072 | Idelalisib | — uncovered |
| UV_RESPONSE_UP | 0.064 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.046 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.039 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.029 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.027 | Inavolisib | — uncovered |