cf37eb41-0595-4a82-a65b-3058902a48d4
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12475107 | — | — | 0.877 |
| 2 | TCGA-AC-A6NO-01A-12R-A33J-07 | — | B | 0.873 |
| 3 | SRR2932822 | — | — | 0.870 |
| 4 | 79227609-ce40-4cf9-a9eb-16732cc2bfc5 | — | — | 0.864 |
| 5 | TCGA-QK-A8Z7-01A-11R-A39I-07 | — | — | 0.864 |
| 6 | TCGA-60-2716-01A-01R-0851-07 | — | cohortSQ1 | 0.862 |
| 7 | TCGA-AN-A0AR-01A-11R-A00Z-07 | — | E | 0.862 |
| 8 | 2d8478f6-41ac-47f5-ac3c-337af7245f5b | — | — | 0.858 |
| 9 | BS_4D9DD103 | medulloblastoma | — | 0.858 |
| 10 | MNG662 | — | — | 0.857 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.510 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.260 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.220 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.160 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.130 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.120 | Temsirolimus | — uncovered |
| G2M_CHECKPOINT | 0.120 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.110 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.080 | Remibrutinib | — uncovered |
| PEROXISOME | 0.070 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.060 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.050 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.020 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.010 | Inavolisib | — uncovered |