SRR1072504
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.290
- OXIDATIVE_PHOSPHORYLATION+0.263
- CHOLESTEROL_HOMEOSTASIS+0.191
- PANCREAS_BETA_CELLS+0.184
- PEROXISOME+0.133
- FATTY_ACID_METABOLISM+0.094
- PROTEIN_SECRETION+0.075
- KRAS_SIGNALING_DN+0.051
- BILE_ACID_METABOLISM+0.043
- MTORC1_SIGNALING+0.043
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.611
- TNFA_SIGNALING_VIA_NFKB-0.546
- INTERFERON_GAMMA_RESPONSE-0.517
- INTERFERON_ALPHA_RESPONSE-0.510
- INFLAMMATORY_RESPONSE-0.492
- TGF_BETA_SIGNALING-0.480
- ALLOGRAFT_REJECTION-0.453
- G2M_CHECKPOINT-0.452
- COMPLEMENT-0.412
- KRAS_SIGNALING_UP-0.409
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1464327 | GTEX | — | 0.956 |
| 2 | SRR1446092 | GTEX | — | 0.926 |
| 3 | SRR1401276 | GTEX | — | 0.922 |
| 4 | SRR1341365 | GTEX | — | 0.917 |
| 5 | SRR821626 | GTEX | — | 0.911 |
| 6 | SRR1452379 | GTEX | — | 0.910 |
| 7 | SRR1311086 | GTEX | — | 0.908 |
| 8 | SRR821549 | GTEX | — | 0.906 |
| 9 | SRR1354013 | GTEX | — | 0.902 |
| 10 | SRR1317596 | GTEX | — | 0.900 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.290 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.263 | Remibrutinib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.191 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.184 | Cobimetinib | — uncovered |
| PEROXISOME | 0.133 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.094 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.075 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.051 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.043 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.043 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.036 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.010 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.002 | Inavolisib | — uncovered |