SRR821626
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1455925 | GTEX | — | 0.980 |
| 2 | SRR1471943 | GTEX | — | 0.978 |
| 3 | SRR1328895 | GTEX | — | 0.976 |
| 4 | SRR1084842 | GTEX | — | 0.973 |
| 5 | SRR1323106 | GTEX | — | 0.972 |
| 6 | SRR661349 | GTEX | — | 0.971 |
| 7 | SRR1362219 | GTEX | — | 0.970 |
| 8 | SRR1360563 | GTEX | — | 0.969 |
| 9 | SRR659235 | GTEX | — | 0.969 |
| 10 | SRR1311086 | GTEX | — | 0.969 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.396 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.252 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.187 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.176 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.169 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.154 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.130 | Cobimetinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.050 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.038 | Inavolisib | — uncovered |
| PEROXISOME | 0.029 | Idelalisib | — uncovered |
| HEME_METABOLISM | 0.017 | Temsirolimus | — uncovered |
| MTORC1_SIGNALING | 0.006 | Inavolisib | — uncovered |