TCGA-A7-A0CG-01A-12R-A056-07

— · A

74161269-2a08-5641-af8d-663ab43c365a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: A
subtype: A
overall_survival_months: 35

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-46-3766-01A-01R-0980-07 lung-landscapes@6	—	cohortSQ1	0.930
2	TCGA-AO-A0JF-01A-11R-A056-07 breast-umap@18	—	A	0.923
3	TCGA-AO-A0JJ-01A-11R-A056-07 breast-umap@18	—	A	0.895
4	TCGA-44-6777-01A-11R-1858-07 lung-landscapes@6	—	cohortA1	0.893
5	TCGA-D8-A1JU-01A-11R-A13Q-07 breast-umap@18	—	A	0.890
6	SRR35579817 breast-umap@18	—	A	0.887
7	d552ba81-1140-4ab6-a14c-659c07e494d0 colon-landscapes@1	—	—	0.884
8	TCGA-38-4627-01A-01R-1206-07 lung-landscapes@6	—	cohortA1	0.882
9	27a08af2-4626-4bf9-bdf6-a6ba644a53a2 colon-landscapes@1	—	—	0.882
10	MDT-AP-3274 medullo-epn-umap@date-based	Med	Medulloblastoma	0.880

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 33 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
KRAS_SIGNALING_UP	0.430	Inavolisib	— uncovered
UV_RESPONSE_DN	0.430	Inavolisib	— uncovered
ALLOGRAFT_REJECTION	0.380	Idelalisib	— uncovered
PROTEIN_SECRETION	0.380	Remibrutinib	— uncovered
ANDROGEN_RESPONSE	0.310	Inavolisib	— uncovered
COMPLEMENT	0.300	Inavolisib	— uncovered
INFLAMMATORY_RESPONSE	0.300	Idelalisib	— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION	0.290	Inavolisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.290	Inavolisib	— uncovered
TGF_BETA_SIGNALING	0.290	Inavolisib	— uncovered
COAGULATION	0.270	Binimetinib	— uncovered
BILE_ACID_METABOLISM	0.240	Inavolisib	— uncovered
PANCREAS_BETA_CELLS	0.240	Cobimetinib	— uncovered
IL2_STAT5_SIGNALING	0.220	Idelalisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.220	Idelalisib	— uncovered
HEME_METABOLISM	0.210	Temsirolimus	— uncovered
NOTCH_SIGNALING	0.200	Inavolisib	— uncovered
XENOBIOTIC_METABOLISM	0.200	Inavolisib	— uncovered
HEDGEHOG_SIGNALING	0.190	Inavolisib	— uncovered
ADIPOGENESIS	0.180	Inavolisib	— uncovered