Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-85-6175-01A-11R-1820-07

· cohortSQ1

756aeef9-5736-5508-b33a-6e3cdeb14512

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortSQ1
subtype
cohortSQ1
age_years
63

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-77-8008-01A-21R-2187-07
lung-landscapes@6
cohortSQ10.943
2TCGA-A2-A0YD-01A-11R-A109-07
breast-umap@18
A0.940
3b02dc7a2-3615-4b6c-a3dd-a866d8561d9d
colon-landscapes@1
0.928
4TCGA-44-6774-01A-21R-1858-07
lung-landscapes@6
cohortA10.920
594f6e4f5-2447-4f1f-9f36-411f1c25a172
colon-landscapes@1
0.913
6X17a4d870.71ef.4580.91db.071219517f26
lung-landscapes@6
cohortSQ10.911
7TCGA-CR-7376-01A-11R-2132-07
head-neck@1
0.904
821196229-e39e-4846-be58-a1055b3ae50e
colon-landscapes@1
0.904
9TCGA-CV-6943-01A-11R-1915-07
head-neck@1
0.901
10f22cfa82-a346-4fed-bc81-21a29bf990ee
colon-landscapes@1
0.901

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.690Inavolisib— uncovered
HEDGEHOG_SIGNALING0.580Inavolisib— uncovered
UV_RESPONSE_DN0.530Inavolisib— uncovered
ANGIOGENESIS0.520Remibrutinib— uncovered
NOTCH_SIGNALING0.490Inavolisib— uncovered
TGF_BETA_SIGNALING0.490Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.480Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.470Inavolisib— uncovered
APICAL_JUNCTION0.430Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.410Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.390Inavolisib— uncovered
IL2_STAT5_SIGNALING0.380Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.380Idelalisib— uncovered
KRAS_SIGNALING_UP0.380Inavolisib— uncovered
COAGULATION0.370Binimetinib— uncovered
HYPOXIA0.370Idelalisib— uncovered
MYOGENESIS0.370Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.360Inavolisib— uncovered
APICAL_SURFACE0.350Temsirolimus— uncovered
ALLOGRAFT_REJECTION0.340Idelalisib— uncovered