Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR1408327

GTEX

78116060-15e3-5d9b-820b-f6e94a611e6f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1444932
brain-umap@2
GTEX0.958
2BS_HHPA8NJ2
medullo-epn-umap@date-based
MedMedulloblastoma0.954
3SRR1323536
brain-umap@2
GTEX0.951
4SRR1389059
brain-umap@2
GTEX0.951
5SRR1319136
brain-umap@2
GTEX0.950
6SRR1334033
brain-umap@2
GTEX0.948
7SRR1499630
brain-umap@2
GTEX0.947
8TCGA-55-6985-01A-11R-1949-07
lung-landscapes@6
cohortA10.945
9SRR1071289
brain-umap@2
GTEX0.944
10SRR1440082
brain-umap@2
GTEX0.944

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
IL6_JAK_STAT3_SIGNALING0.444Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.444Idelalisib— uncovered
COAGULATION0.422Binimetinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.414Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.380Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.343Inavolisib— uncovered
KRAS_SIGNALING_DN0.329Remibrutinib— uncovered
COMPLEMENT0.327Inavolisib— uncovered
KRAS_SIGNALING_UP0.327Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.317Idelalisib— uncovered
PANCREAS_BETA_CELLS0.306Cobimetinib— uncovered
ALLOGRAFT_REJECTION0.300Idelalisib— uncovered
APICAL_SURFACE0.261Temsirolimus— uncovered
ANGIOGENESIS0.238Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.237Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.230Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.218Inavolisib— uncovered
APOPTOSIS0.217Idelalisib— uncovered
MYOGENESIS0.217Inavolisib— uncovered
HYPOXIA0.214Idelalisib— uncovered