SRR1311285
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.326
- OXIDATIVE_PHOSPHORYLATION+0.314
- SPERMATOGENESIS+0.284
- MYOGENESIS+0.083
- PANCREAS_BETA_CELLS+0.076
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.039
- HEDGEHOG_SIGNALING-0.006
- ESTROGEN_RESPONSE_LATE-0.044
- BILE_ACID_METABOLISM-0.104
- ESTROGEN_RESPONSE_EARLY-0.111
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.518
- INTERFERON_ALPHA_RESPONSE-0.512
- INTERFERON_GAMMA_RESPONSE-0.473
- MTORC1_SIGNALING-0.471
- TNFA_SIGNALING_VIA_NFKB-0.471
- CHOLESTEROL_HOMEOSTASIS-0.449
- G2M_CHECKPOINT-0.446
- UNFOLDED_PROTEIN_RESPONSE-0.428
- E2F_TARGETS-0.426
- MYC_TARGETS_V2-0.411
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1335651 | GTEX | — | 0.974 |
| 2 | SRR1471435 | GTEX | — | 0.973 |
| 3 | SRR1374221 | GTEX | — | 0.972 |
| 4 | SRR1367870 | GTEX | — | 0.969 |
| 5 | SRR1340907 | GTEX | — | 0.969 |
| 6 | SRR1413625 | GTEX | — | 0.968 |
| 7 | SRR1418923 | GTEX | — | 0.968 |
| 8 | SRR1324431 | GTEX | — | 0.964 |
| 9 | SRR1070986 | GTEX | — | 0.962 |
| 10 | SRR1487107 | GTEX | — | 0.961 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.326 | Remibrutinib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.314 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.284 | Inavolisib | — uncovered |
| MYOGENESIS | 0.083 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.076 | Cobimetinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.039 | Inavolisib | — uncovered |