SRR1413625
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.360
- KRAS_SIGNALING_DN+0.359
- MYOGENESIS+0.284
- OXIDATIVE_PHOSPHORYLATION+0.239
- PANCREAS_BETA_CELLS+0.083
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.042
- ESTROGEN_RESPONSE_LATE+0.015
- BILE_ACID_METABOLISM+0.003
- APICAL_JUNCTION-0.001
- APICAL_SURFACE-0.009
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.482
- IL6_JAK_STAT3_SIGNALING-0.467
- NOTCH_SIGNALING-0.446
- INTERFERON_GAMMA_RESPONSE-0.413
- CHOLESTEROL_HOMEOSTASIS-0.406
- G2M_CHECKPOINT-0.395
- MYC_TARGETS_V1-0.386
- E2F_TARGETS-0.382
- UNFOLDED_PROTEIN_RESPONSE-0.380
- MTORC1_SIGNALING-0.369
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1311285 | GTEX | — | 0.968 |
| 2 | SRR1418923 | GTEX | — | 0.965 |
| 3 | SRR1365987 | GTEX | — | 0.963 |
| 4 | SRR817797 | GTEX | — | 0.959 |
| 5 | SRR1458134 | GTEX | — | 0.956 |
| 6 | SRR1403050 | GTEX | — | 0.955 |
| 7 | SRR1487107 | GTEX | — | 0.953 |
| 8 | SRR819134 | GTEX | — | 0.952 |
| 9 | SRR1474509 | GTEX | — | 0.951 |
| 10 | SRR1374221 | GTEX | — | 0.949 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.360 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.359 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.284 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.239 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.083 | Cobimetinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.042 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.015 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.003 | Inavolisib | — uncovered |