Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

AUR-AF98-TTM1-A-1-1-R-A742-41

· E

78732000-f64b-58ee-8bb4-d183d03803a9

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
E
subtype
E

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-E7-A7DV-01A-11R-A33J-07
bladder-landscape@3
0.878
2SRR6013500
lung-landscapes@6
cohortA10.875
3A2170829-B80C-49F2-8FB6-39B8ACFB27CB
brain-umap@2
0.872
427875588-7C41-49BB-A4C0-A66D72A12499
brain-umap@2
0.871
5SRR6013499
lung-landscapes@6
cohortA10.871
6F2EB65DD-59F7-4C1F-8D92-0DCF439FF41A
brain-umap@2
0.870
7SRR8518316
breast-umap@18
D0.870
8TCGA-A2-A0SV-01A-11R-A084-07
breast-umap@18
C0.869
9BS_JG9JZTA9
brain-umap@2
low-grade glioma0.861
10DB8DD33B-34B6-4F4B-AD87-D666899A26BC
brain-umap@2
0.860

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 39 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.560Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.520Remibrutinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.500Inavolisib— uncovered
ALLOGRAFT_REJECTION0.490Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.470Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.470Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.470Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.440Idelalisib— uncovered
GLYCOLYSIS0.430Inavolisib— uncovered
MYC_TARGETS_V10.430Inavolisib— uncovered
MTORC1_SIGNALING0.400Inavolisib— uncovered
COMPLEMENT0.380Inavolisib— uncovered
ANGIOGENESIS0.350Remibrutinib— uncovered
ADIPOGENESIS0.340Inavolisib— uncovered
E2F_TARGETS0.300Inavolisib— uncovered
HYPOXIA0.300Idelalisib— uncovered
UV_RESPONSE_UP0.270Idelalisib— uncovered
PROTEIN_SECRETION0.260Remibrutinib— uncovered
KRAS_SIGNALING_UP0.250Inavolisib— uncovered
FATTY_ACID_METABOLISM0.220Inavolisib— uncovered