8cace84b-8d01-46cf-8b59-9f1e53249863
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 81
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.330
- UV_RESPONSE_DN+0.320
- PROTEIN_SECRETION+0.270
- G2M_CHECKPOINT+0.230
- ANDROGEN_RESPONSE+0.210
- PEROXISOME+0.190
- MITOTIC_SPINDLE+0.180
- E2F_TARGETS+0.150
- SPERMATOGENESIS+0.150
- BILE_ACID_METABOLISM+0.080
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.430
- INTERFERON_GAMMA_RESPONSE-0.390
- IL6_JAK_STAT3_SIGNALING-0.370
- INFLAMMATORY_RESPONSE-0.350
- ALLOGRAFT_REJECTION-0.340
- TNFA_SIGNALING_VIA_NFKB-0.340
- CHOLESTEROL_HOMEOSTASIS-0.310
- P53_PATHWAY-0.310
- HYPOXIA-0.300
- IL2_STAT5_SIGNALING-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-E9-A1R7-01A-11R-A14M-07 | — | B | 0.838 |
| 2 | MNG673 | — | — | 0.835 |
| 3 | MNG522 | — | — | 0.827 |
| 4 | 959c268c-637f-4f39-a254-a505c57e8448 | — | — | 0.824 |
| 5 | de92b16c-4549-4025-9885-76c260c30cf7 | — | — | 0.823 |
| 6 | MDT-AP-3325 | Med | Medulloblastoma | 0.815 |
| 7 | MDT-AP-3311 | Med | Medulloblastoma | 0.815 |
| 8 | TCGA-D8-A1XR-01A-11R-A14M-07 | — | B | 0.812 |
| 9 | MNG420 | — | — | 0.806 |
| 10 | 2e15a781-21c1-421b-9e92-6d2d414e0d14 | — | — | 0.805 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.330 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.320 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.270 | Remibrutinib | — uncovered |
| G2M_CHECKPOINT | 0.230 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.210 | Inavolisib | — uncovered |
| PEROXISOME | 0.190 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.180 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.150 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.150 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.080 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.080 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.080 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.050 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.050 | Inavolisib | — uncovered |