Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_GNV89A5P

Med · Medulloblastoma

7dc4cc1a-049d-5cb9-8a90-9596ad572088

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Med
cancer_type_detailed
subtype
Medulloblastoma
cancer_type
Med
subtype
Medulloblastoma
overall_survival_months
105.84
os_event
false
age_years
10.564
sex
F
race
White
new_clusters
C6
umap1_2d
3.078132974
umap2_2d
6.095253538
umap1_3d
1.751977454
umap2_3d
-0.728538709
umap3_3d
-4.57740798
dataset
Med-CBTN

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • E2F_TARGETS+0.500
  • PROTEIN_SECRETION+0.470
  • DNA_REPAIR+0.390
  • G2M_CHECKPOINT+0.390
  • MYC_TARGETS_V1+0.310
  • OXIDATIVE_PHOSPHORYLATION+0.310
  • MITOTIC_SPINDLE+0.240
  • PI3K_AKT_MTOR_SIGNALING+0.190
  • FATTY_ACID_METABOLISM+0.170
  • WNT_BETA_CATENIN_SIGNALING+0.160

Top 10 suppressed

  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.440
  • ALLOGRAFT_REJECTION-0.430
  • INFLAMMATORY_RESPONSE-0.410
  • KRAS_SIGNALING_DN-0.400
  • INTERFERON_ALPHA_RESPONSE-0.390
  • INTERFERON_GAMMA_RESPONSE-0.360
  • TNFA_SIGNALING_VIA_NFKB-0.350
  • IL2_STAT5_SIGNALING-0.340
  • KRAS_SIGNALING_UP-0.340
  • COAGULATION-0.330

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_4CP4T22V
medullo-epn-umap@date-based
MedMedulloblastoma0.940
2MDT-AP-3307
medullo-epn-umap@date-based
MedMedulloblastoma0.903
3MDT-AP-0357
medullo-epn-umap@date-based
MedMedulloblastoma0.899
4MDT-AP-0156
medullo-epn-umap@date-based
MedMedulloblastoma0.894
5BS_HF3RNN2T
medullo-epn-umap@date-based
MedMedulloblastoma0.894
6MDT-AP-3088
medullo-epn-umap@date-based
MedMedulloblastoma0.891
7MDT-AP-0113
medullo-epn-umap@date-based
MedMedulloblastoma0.887
8MDT-AP-0553
medullo-epn-umap@date-based
MedMedulloblastoma0.885
9BS_J8G4SH4Z
medullo-epn-umap@date-based
MedMedulloblastoma0.884
10SRR23303743
bladder-landscape@3
0.881

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 18 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.500Inavolisib— uncovered
PROTEIN_SECRETION0.470Remibrutinib— uncovered
DNA_REPAIR0.390Idelalisib— uncovered
G2M_CHECKPOINT0.390Inavolisib— uncovered
MYC_TARGETS_V10.310Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.310Remibrutinib— uncovered
MITOTIC_SPINDLE0.240Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.190Inavolisib— uncovered
FATTY_ACID_METABOLISM0.170Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.160Inavolisib— uncovered
HEME_METABOLISM0.140Temsirolimus— uncovered
ADIPOGENESIS0.120Inavolisib— uncovered
PEROXISOME0.120Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.090Idelalisib— uncovered
HEDGEHOG_SIGNALING0.070Inavolisib— uncovered
SPERMATOGENESIS0.040Inavolisib— uncovered
MTORC1_SIGNALING0.010Inavolisib— uncovered
TGF_BETA_SIGNALING0.010Inavolisib— uncovered