Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-E9-A3Q9-01A-11R-A21T-07

· B

7edf90c1-6c48-5f55-8ac0-635b4bf157fc

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
33
os_event
false

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PANCREAS_BETA_CELLS+0.330
  • KRAS_SIGNALING_DN+0.270
  • BILE_ACID_METABOLISM+0.220
  • ESTROGEN_RESPONSE_LATE+0.210
  • COAGULATION+0.190
  • MYOGENESIS+0.190
  • INFLAMMATORY_RESPONSE+0.170
  • XENOBIOTIC_METABOLISM+0.170
  • KRAS_SIGNALING_UP+0.160
  • ESTROGEN_RESPONSE_EARLY+0.120

Top 10 suppressed

  • MYC_TARGETS_V2-0.720
  • MYC_TARGETS_V1-0.700
  • E2F_TARGETS-0.660
  • G2M_CHECKPOINT-0.660
  • MITOTIC_SPINDLE-0.560
  • UNFOLDED_PROTEIN_RESPONSE-0.510
  • DNA_REPAIR-0.500
  • OXIDATIVE_PHOSPHORYLATION-0.490
  • PROTEIN_SECRETION-0.460
  • PI3K_AKT_MTOR_SIGNALING-0.450

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1TCGA-NJ-A55O-01A-11R-A262-07
lung-landscapes@6
cohortA20.944
2TCGA-97-8552-01A-11R-2403-07
lung-landscapes@6
cohortA10.917
3sclc1020_S66.txt
lung-landscapes@6
cohortA10.913
4TCGA-62-8397-01A-11R-2326-07
lung-landscapes@6
cohortA10.913
5BS_912NX4Y0
brain-umap@2
Ganglioglioma0.905
6TCGA-97-A4M2-01A-12R-A24X-07
lung-landscapes@6
cohortA10.901
7MDT-AP-0813
medullo-epn-umap@date-based
MedMedulloblastoma0.901
8MDT-AP-0208
medullo-epn-umap@date-based
MedMedulloblastoma0.899
9BS_EXYHZ6D4
brain-umap@2
pilocytic astrocytoma0.893
10BS_AKRHBPNZ
brain-umap@2
Ganglioglioma0.890

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 16 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.330Cobimetinib— uncovered
KRAS_SIGNALING_DN0.270Remibrutinib— uncovered
BILE_ACID_METABOLISM0.220Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.210Idelalisib— uncovered
COAGULATION0.190Binimetinib— uncovered
MYOGENESIS0.190Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.170Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.170Inavolisib— uncovered
KRAS_SIGNALING_UP0.160Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.120Inavolisib— uncovered
FATTY_ACID_METABOLISM0.120Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.110Inavolisib— uncovered
APICAL_SURFACE0.080Temsirolimus— uncovered
ALLOGRAFT_REJECTION0.030Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.030Inavolisib— uncovered
IL2_STAT5_SIGNALING0.020Idelalisib— uncovered