Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_AKRHBPNZ

Ganglioglioma

d522583a-871e-5994-b847-b5c9c1f7a2e4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Ganglioglioma
cancer_type_detailed
subtype
cancer_type
Ganglioglioma
age_years
7.441
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.469
  • MYOGENESIS+0.393
  • BILE_ACID_METABOLISM+0.342
  • PANCREAS_BETA_CELLS+0.302
  • XENOBIOTIC_METABOLISM+0.242
  • HEDGEHOG_SIGNALING+0.206
  • ESTROGEN_RESPONSE_EARLY+0.205
  • APICAL_SURFACE+0.163
  • KRAS_SIGNALING_UP+0.156
  • COAGULATION+0.122

Top 10 suppressed

  • MYC_TARGETS_V1-0.742
  • MYC_TARGETS_V2-0.660
  • E2F_TARGETS-0.648
  • G2M_CHECKPOINT-0.619
  • UNFOLDED_PROTEIN_RESPONSE-0.615
  • PROTEIN_SECRETION-0.548
  • DNA_REPAIR-0.546
  • MTORC1_SIGNALING-0.424
  • MITOTIC_SPINDLE-0.423
  • TGF_BETA_SIGNALING-0.414

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_912NX4Y0
brain-umap@2
Ganglioglioma0.957
2SRR1333352
brain-umap@2
GTEX0.940
3BS_QV51J756
brain-umap@2
Ganglioglioma0.940
4SRR1472323
brain-umap@2
GTEX0.937
5SRR1323174
brain-umap@2
GTEX0.936
6MNG768
mng-umap@100
0.933
7SRR1381673
brain-umap@2
GTEX0.927
8TCGA-62-8397-01A-11R-2326-07
lung-landscapes@6
cohortA10.926
9BS_ZR96A4FH
brain-umap@2
DNET0.924
10BS_398KYV92
brain-umap@2
Meningioma0.922

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 19 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.469Remibrutinib— uncovered
MYOGENESIS0.393Inavolisib— uncovered
BILE_ACID_METABOLISM0.342Inavolisib— uncovered
PANCREAS_BETA_CELLS0.302Cobimetinib— uncovered
XENOBIOTIC_METABOLISM0.242Inavolisib— uncovered
HEDGEHOG_SIGNALING0.206Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.205Inavolisib— uncovered
APICAL_SURFACE0.163Temsirolimus— uncovered
KRAS_SIGNALING_UP0.156Inavolisib— uncovered
COAGULATION0.122Binimetinib— uncovered
APICAL_JUNCTION0.121Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.093Idelalisib— uncovered
NOTCH_SIGNALING0.078Inavolisib— uncovered
SPERMATOGENESIS0.075Inavolisib— uncovered
UV_RESPONSE_DN0.060Inavolisib— uncovered
FATTY_ACID_METABOLISM0.055Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.042Remibrutinib— uncovered
P53_PATHWAY0.015Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.012Idelalisib— uncovered