SRR1379562
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.360
- SPERMATOGENESIS+0.116
- MYOGENESIS+0.043
- PANCREAS_BETA_CELLS+0.001
- WNT_BETA_CATENIN_SIGNALING+0.000
- APICAL_SURFACE-0.003
- XENOBIOTIC_METABOLISM-0.024
- APICAL_JUNCTION-0.061
- UV_RESPONSE_UP-0.069
- ESTROGEN_RESPONSE_EARLY-0.093
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.535
- INTERFERON_GAMMA_RESPONSE-0.444
- INFLAMMATORY_RESPONSE-0.405
- TGF_BETA_SIGNALING-0.405
- MYC_TARGETS_V1-0.391
- APOPTOSIS-0.381
- PROTEIN_SECRETION-0.375
- IL6_JAK_STAT3_SIGNALING-0.373
- ALLOGRAFT_REJECTION-0.366
- MTORC1_SIGNALING-0.362
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1093527 | GTEX | — | 0.963 |
| 2 | SRR1467813 | GTEX | — | 0.956 |
| 3 | SRR1350107 | GTEX | — | 0.956 |
| 4 | SRR1388504 | GTEX | — | 0.952 |
| 5 | SRR1436444 | GTEX | — | 0.949 |
| 6 | SRR1479802 | GTEX | — | 0.946 |
| 7 | BS_J71N7D09 | medulloblastoma | — | 0.943 |
| 8 | SRR1368178 | GTEX | — | 0.939 |
| 9 | SRR1413414 | GTEX | — | 0.939 |
| 10 | SRR1348021 | GTEX | — | 0.933 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.360 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.116 | Inavolisib | — uncovered |
| MYOGENESIS | 0.043 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.001 | Cobimetinib | — uncovered |