SRR1093527
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.279
- MYOGENESIS+0.201
- SPERMATOGENESIS+0.090
- UV_RESPONSE_UP+0.001
- APICAL_SURFACE-0.024
- MYC_TARGETS_V2-0.058
- APICAL_JUNCTION-0.078
- PI3K_AKT_MTOR_SIGNALING-0.085
- MITOTIC_SPINDLE-0.100
- HYPOXIA-0.104
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.576
- INTERFERON_GAMMA_RESPONSE-0.472
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.424
- TGF_BETA_SIGNALING-0.415
- INFLAMMATORY_RESPONSE-0.370
- NOTCH_SIGNALING-0.365
- KRAS_SIGNALING_UP-0.364
- OXIDATIVE_PHOSPHORYLATION-0.359
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.345
- ANGIOGENESIS-0.344
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1379562 | GTEX | — | 0.963 |
| 2 | SRR1479802 | GTEX | — | 0.958 |
| 3 | SRR1348021 | GTEX | — | 0.956 |
| 4 | SRR1413414 | GTEX | — | 0.955 |
| 5 | SRR1434250 | GTEX | — | 0.955 |
| 6 | SRR1434271 | GTEX | — | 0.952 |
| 7 | SRR1467813 | GTEX | — | 0.952 |
| 8 | SRR1388504 | GTEX | — | 0.948 |
| 9 | SRR1453214 | GTEX | — | 0.947 |
| 10 | SRR1431366 | GTEX | — | 0.946 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.279 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.201 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.090 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.001 | Idelalisib | — uncovered |