MNG182
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.412
- G2M_CHECKPOINT+0.395
- MITOTIC_SPINDLE+0.265
- MYC_TARGETS_V1+0.255
- SPERMATOGENESIS+0.232
- INTERFERON_ALPHA_RESPONSE+0.096
- UV_RESPONSE_DN+0.094
- MYC_TARGETS_V2+0.069
- PEROXISOME+0.021
- FATTY_ACID_METABOLISM+0.013
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.447
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.436
- WNT_BETA_CATENIN_SIGNALING-0.404
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.398
- APOPTOSIS-0.386
- TGF_BETA_SIGNALING-0.374
- CHOLESTEROL_HOMEOSTASIS-0.344
- P53_PATHWAY-0.339
- HYPOXIA-0.307
- IL2_STAT5_SIGNALING-0.281
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SAMN03290905 | — | — | 0.861 |
| 2 | C3N-02728 | — | cohortMD1 | 0.859 |
| 3 | SAMN03290898 | — | — | 0.847 |
| 4 | R160 | — | — | 0.840 |
| 5 | TCGA-BB-4223-01A-01R-1436-07 | — | — | 0.836 |
| 6 | SRR934790 | — | — | 0.833 |
| 7 | BS_YEW22W35 | high-grade glioma | — | 0.832 |
| 8 | SRR12202476 | — | — | 0.825 |
| 9 | SRR975551 | — | — | 0.822 |
| 10 | BS_7FWZ518S | medulloblastoma | — | 0.821 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.412 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.395 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.265 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.255 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.232 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.096 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.094 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.069 | Idelalisib | — uncovered |
| PEROXISOME | 0.021 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.013 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.004 | Remibrutinib | — uncovered |