SAMN03290898
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.400
- G2M_CHECKPOINT+0.300
- MYC_TARGETS_V2+0.200
- PROTEIN_SECRETION+0.200
- MITOTIC_SPINDLE+0.100
- MYC_TARGETS_V1+0.100
- SPERMATOGENESIS+0.100
- OXIDATIVE_PHOSPHORYLATION+0.000
- UNFOLDED_PROTEIN_RESPONSE+0.000
- ANDROGEN_RESPONSE-0.100
Top 10 suppressed
- ANGIOGENESIS-0.600
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.600
- TGF_BETA_SIGNALING-0.500
- TNFA_SIGNALING_VIA_NFKB-0.500
- APICAL_JUNCTION-0.400
- COAGULATION-0.400
- COMPLEMENT-0.400
- HYPOXIA-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_2A5R9MEJ | high-grade glioma | — | 0.913 |
| 2 | ERR2208947 | — | — | 0.913 |
| 3 | 7cd1f8af-7c1d-4a56-a617-b8debf493122 | — | — | 0.912 |
| 4 | s_150324_3b | EPN | Posterior Fossa EPN | 0.910 |
| 5 | SRR1313143 | — | E | 0.906 |
| 6 | SRR655864 | GTEX | — | 0.905 |
| 7 | R160 | — | — | 0.904 |
| 8 | SRR661290 | GTEX | — | 0.904 |
| 9 | SRR975551 | — | — | 0.900 |
| 10 | 24975492-6b9f-445b-9f6b-daee2f8363d3 | — | — | 0.899 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.400 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.300 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.200 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.200 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.100 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.100 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.100 | Inavolisib | — uncovered |