Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934816

81fcccd0-8979-53e1-b4af-80bded5521c2

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
16.52431011826544
age_years
51
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.647
  • ANGIOGENESIS+0.621
  • IL6_JAK_STAT3_SIGNALING+0.564
  • TNFA_SIGNALING_VIA_NFKB+0.552
  • INTERFERON_GAMMA_RESPONSE+0.546
  • INTERFERON_ALPHA_RESPONSE+0.529
  • TGF_BETA_SIGNALING+0.503
  • HYPOXIA+0.501
  • ALLOGRAFT_REJECTION+0.485
  • INFLAMMATORY_RESPONSE+0.485

Top 10 suppressed

  • SPERMATOGENESIS-0.389
  • KRAS_SIGNALING_DN-0.380
  • OXIDATIVE_PHOSPHORYLATION-0.241
  • PANCREAS_BETA_CELLS-0.240
  • BILE_ACID_METABOLISM-0.025
  • MYOGENESIS-0.006
  • FATTY_ACID_METABOLISM+0.005
  • WNT_BETA_CATENIN_SIGNALING+0.030
  • PEROXISOME+0.051
  • HEME_METABOLISM+0.052

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934829
brain-umap@2
0.980
2SRR934782
brain-umap@2
0.977
3SRR934845
brain-umap@2
0.976
4SRR934866
brain-umap@2
0.972
5SRR934750
brain-umap@2
0.968
6SRR934926
brain-umap@2
0.966
718D7DFBC-A1C6-4DA8-9AF1-3A6F3E2A03BE
brain-umap@2
0.965
8SRR934747
brain-umap@2
0.961
9SRR934825
brain-umap@2
0.960
10SRR934952
brain-umap@2
0.959

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 44 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.647Inavolisib— uncovered
ANGIOGENESIS0.621Remibrutinib— uncovered
IL6_JAK_STAT3_SIGNALING0.564Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.552Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.546Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.529Inavolisib— uncovered
TGF_BETA_SIGNALING0.503Inavolisib— uncovered
HYPOXIA0.501Idelalisib— uncovered
ALLOGRAFT_REJECTION0.485Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.485Idelalisib— uncovered
G2M_CHECKPOINT0.478Inavolisib— uncovered
UV_RESPONSE_DN0.460Inavolisib— uncovered
PROTEIN_SECRETION0.454Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.451Idelalisib— uncovered
APOPTOSIS0.438Idelalisib— uncovered
ANDROGEN_RESPONSE0.416Inavolisib— uncovered
COMPLEMENT0.403Inavolisib— uncovered
GLYCOLYSIS0.380Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.374Idelalisib— uncovered
MTORC1_SIGNALING0.373Inavolisib— uncovered