MNG526
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.323
- HEME_METABOLISM+0.260
- UV_RESPONSE_DN+0.251
- TGF_BETA_SIGNALING+0.223
- PEROXISOME+0.197
- BILE_ACID_METABOLISM+0.183
- ANDROGEN_RESPONSE+0.178
- ESTROGEN_RESPONSE_EARLY+0.172
- HEDGEHOG_SIGNALING+0.128
- MITOTIC_SPINDLE+0.124
Top 10 suppressed
- ANGIOGENESIS-0.414
- IL6_JAK_STAT3_SIGNALING-0.384
- E2F_TARGETS-0.368
- TNFA_SIGNALING_VIA_NFKB-0.368
- G2M_CHECKPOINT-0.367
- OXIDATIVE_PHOSPHORYLATION-0.354
- INFLAMMATORY_RESPONSE-0.340
- MTORC1_SIGNALING-0.316
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.303
- MYC_TARGETS_V2-0.263
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG699 | — | — | 0.835 |
| 2 | MNG320 | — | — | 0.820 |
| 3 | TCGA-E2-A15P-01A-11R-A115-07 | — | B | 0.814 |
| 4 | TCGA-86-8073-01A-11R-2241-07 | — | cohortA1 | 0.786 |
| 5 | SRR1313106 | — | B | 0.781 |
| 6 | TCGA-44-6147-01A-11R-A278-07 | — | cohortMD2 | 0.773 |
| 7 | MNG1049 | — | — | 0.772 |
| 8 | TCGA-44-6146-01A-11R-A278-07 | — | cohortA1 | 0.768 |
| 9 | TCGA-OR-A5JW-01 | Adrenocortical Carcinoma | Adrenocortical Carcinoma, Usual Type | 0.766 |
| 10 | TCGA-E2-A1IL-01A-11R-A14D-07 | — | B | 0.765 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 16 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.323 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.260 | Temsirolimus | — uncovered |
| UV_RESPONSE_DN | 0.251 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.223 | Inavolisib | — uncovered |
| PEROXISOME | 0.197 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.183 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.178 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.172 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.128 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.124 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.101 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.063 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.061 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.029 | Temsirolimus | — uncovered |
| NOTCH_SIGNALING | 0.019 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.010 | Inavolisib | — uncovered |