Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG699

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c0355186-0dd5-5ea0-9813-717ec830670f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MITOTIC_SPINDLE+0.327
  • PEROXISOME+0.302
  • UV_RESPONSE_DN+0.264
  • PROTEIN_SECRETION+0.263
  • WNT_BETA_CATENIN_SIGNALING+0.234
  • INTERFERON_ALPHA_RESPONSE+0.222
  • ANDROGEN_RESPONSE+0.205
  • TGF_BETA_SIGNALING+0.204
  • ESTROGEN_RESPONSE_EARLY+0.191
  • HEDGEHOG_SIGNALING+0.185

Top 10 suppressed

  • TNFA_SIGNALING_VIA_NFKB-0.388
  • ANGIOGENESIS-0.379
  • IL6_JAK_STAT3_SIGNALING-0.334
  • OXIDATIVE_PHOSPHORYLATION-0.317
  • INFLAMMATORY_RESPONSE-0.307
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.282
  • MYC_TARGETS_V1-0.233
  • KRAS_SIGNALING_UP-0.228
  • MYC_TARGETS_V2-0.222
  • COAGULATION-0.214

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG526
mng-umap@100
——0.835
2MNG320
mng-umap@100
——0.790
3MNG920
mng-umap@100
——0.753
4MNG522
mng-umap@100
——0.743
5MNG940
mng-umap@100
——0.731
6TCGA-E2-A15P-01A-11R-A115-07
breast-umap@18
—B0.721
7MNG108
mng-umap@100
——0.718
8MNG607
mng-umap@100
——0.710
9MNG1049
mng-umap@100
——0.690
10MNG677
mng-umap@100
——0.687

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 20 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MITOTIC_SPINDLE0.327Inavolisib— uncovered
PEROXISOME0.302Idelalisib— uncovered
UV_RESPONSE_DN0.264Inavolisib— uncovered
PROTEIN_SECRETION0.263Remibrutinib— uncovered
WNT_BETA_CATENIN_SIGNALING0.234Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.222Inavolisib— uncovered
ANDROGEN_RESPONSE0.205Inavolisib— uncovered
TGF_BETA_SIGNALING0.204Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.191Inavolisib— uncovered
HEDGEHOG_SIGNALING0.185Inavolisib— uncovered
BILE_ACID_METABOLISM0.175Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.141Remibrutinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.119Inavolisib— uncovered
HEME_METABOLISM0.110Temsirolimus— uncovered
ADIPOGENESIS0.056Inavolisib— uncovered
APICAL_JUNCTION0.053Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.043Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.026Idelalisib— uncovered
NOTCH_SIGNALING0.019Inavolisib— uncovered
APICAL_SURFACE0.001Temsirolimus— uncovered