Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_8T7DZV2F

medulloblastoma

85d23834-3d15-5c92-b5a2-ca464927cef1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
medulloblastoma
cancer_type_detailed
subtype
cancer_type
medulloblastoma
overall_survival_months
8.114323258869907
age_years
15.375
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_KE56MMY0
brain-umap@2
Neurofibroma0.926
2SRR934958
brain-umap@2
0.896
38B4E465B-0FD5-4154-824B-1E6B2656FD2F
brain-umap@2
0.893
4F873381B-3D15-47B2-9385-080590B316B7
brain-umap@2
0.892
5SRR934839
brain-umap@2
0.889
6BS_0WQJP6ZG
brain-umap@2
Supratentorial Ependymoma0.888
7fca4c327-dfab-4455-84a8-f890a7326132
colon-landscapes@1
0.886
8SRR934965
brain-umap@2
0.886
9SRR934730
brain-umap@2
0.883
101B940F72-3C90-43C4-9267-185F21D10AC9
brain-umap@2
0.882

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 42 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V10.598Inavolisib— uncovered
MYC_TARGETS_V20.528Idelalisib— uncovered
E2F_TARGETS0.522Inavolisib— uncovered
G2M_CHECKPOINT0.475Inavolisib— uncovered
ALLOGRAFT_REJECTION0.440Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.436Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.432Idelalisib— uncovered
PROTEIN_SECRETION0.425Remibrutinib— uncovered
ANGIOGENESIS0.376Remibrutinib— uncovered
IL6_JAK_STAT3_SIGNALING0.324Inavolisib— uncovered
MTORC1_SIGNALING0.323Inavolisib— uncovered
ANDROGEN_RESPONSE0.316Inavolisib— uncovered
TGF_BETA_SIGNALING0.312Inavolisib— uncovered
IL2_STAT5_SIGNALING0.295Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.294Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.288Remibrutinib— uncovered
DNA_REPAIR0.287Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.285Idelalisib— uncovered
P53_PATHWAY0.274Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.274Inavolisib— uncovered