Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-CV-6938-01A-11R-1915-07

863c3cb2-17fb-575a-8302-64dc0c79678b

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0.032876712
sex
male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.770
  • INTERFERON_GAMMA_RESPONSE+0.700
  • ALLOGRAFT_REJECTION+0.580
  • MYC_TARGETS_V1+0.480
  • MYC_TARGETS_V2+0.470
  • INFLAMMATORY_RESPONSE+0.440
  • COMPLEMENT+0.410
  • OXIDATIVE_PHOSPHORYLATION+0.410
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.380
  • P53_PATHWAY+0.360

Top 10 suppressed

  • MYOGENESIS-0.430
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.370
  • HEDGEHOG_SIGNALING-0.290
  • HYPOXIA-0.260
  • KRAS_SIGNALING_DN-0.220
  • SPERMATOGENESIS-0.180
  • WNT_BETA_CATENIN_SIGNALING-0.160
  • UV_RESPONSE_DN-0.140
  • ESTROGEN_RESPONSE_EARLY-0.070
  • ESTROGEN_RESPONSE_LATE+0.010

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_GJNCYABP
brain-umap@2
ATRT0.876
2SJEPD030292_D1.RNA-Seq
medullo-epn-umap@date-based
EPNSupratentorial EPN0.871
3SRR6013516
lung-landscapes@6
cohortA10.866
48f1213be-da41-4cd6-97b2-f9fce1ea00ff
colon-landscapes@1
0.859
5SRR12696807
melanoma-umap@29
0.858
6896B5096-D888-4DC3-9C70-152BDE083E26
brain-umap@2
0.856
7BS_8GW1TMV2
medullo-epn-umap@date-based
MedMedulloblastoma0.855
8TCGA-BA-5152-01A-02R-1873-07
head-neck@1
0.848
9TCGA-39-5011-01A-01R-1443-07
lung-landscapes@6
cohortA10.846
106D1D9992-DA2B-419A-A80A-9EBCDA831754
brain-umap@2
0.845

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.770Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.700Idelalisib— uncovered
ALLOGRAFT_REJECTION0.580Idelalisib— uncovered
MYC_TARGETS_V10.480Inavolisib— uncovered
MYC_TARGETS_V20.470Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.440Idelalisib— uncovered
COMPLEMENT0.410Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.410Remibrutinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.380Inavolisib— uncovered
P53_PATHWAY0.360Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.350Inavolisib— uncovered
PEROXISOME0.320Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.310Remibrutinib— uncovered
PROTEIN_SECRETION0.310Remibrutinib— uncovered
APOPTOSIS0.300Idelalisib— uncovered
MTORC1_SIGNALING0.300Inavolisib— uncovered
ANDROGEN_RESPONSE0.270Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.270Inavolisib— uncovered
DNA_REPAIR0.260Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.260Idelalisib— uncovered