Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-GC-A6I1-01A-12R-A31N-07

86d916b5-1488-566e-8775-ffbaa817d560

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0
os_event
true
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.640
  • ALLOGRAFT_REJECTION+0.600
  • INTERFERON_GAMMA_RESPONSE+0.590
  • MYC_TARGETS_V2+0.540
  • INFLAMMATORY_RESPONSE+0.530
  • MYC_TARGETS_V1+0.530
  • IL6_JAK_STAT3_SIGNALING+0.510
  • TNFA_SIGNALING_VIA_NFKB+0.490
  • MTORC1_SIGNALING+0.470
  • UNFOLDED_PROTEIN_RESPONSE+0.460

Top 10 suppressed

  • HEDGEHOG_SIGNALING-0.350
  • NOTCH_SIGNALING-0.270
  • ESTROGEN_RESPONSE_EARLY-0.250
  • MITOTIC_SPINDLE-0.230
  • UV_RESPONSE_DN-0.200
  • MYOGENESIS-0.130
  • BILE_ACID_METABOLISM-0.110
  • APICAL_SURFACE-0.080
  • SPERMATOGENESIS-0.070
  • WNT_BETA_CATENIN_SIGNALING-0.070

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_GJNCYABP
brain-umap@2
ATRT0.920
2TCGA-DK-A3WW-01A-22R-A23N-07
bladder-landscape@3
0.916
3TCGA-BA-A6DJ-01A-11R-A30B-07
head-neck@1
0.912
48f1213be-da41-4cd6-97b2-f9fce1ea00ff
colon-landscapes@1
0.911
5F2EB65DD-59F7-4C1F-8D92-0DCF439FF41A
brain-umap@2
0.909
6TCGA-ZF-A9RD-01A-11R-A42T-07
bladder-landscape@3
0.898
7DF145DF3-D7FD-48C9-ADC8-0B8618DC65A8
brain-umap@2
0.896
8MDT-AP-2036
medullo-epn-umap@date-based
MedMedulloblastoma0.896
9A2170829-B80C-49F2-8FB6-39B8ACFB27CB
brain-umap@2
0.896
10MNG1188
mng-umap@100
0.896

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.640Inavolisib— uncovered
ALLOGRAFT_REJECTION0.600Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.590Idelalisib— uncovered
MYC_TARGETS_V20.540Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.530Idelalisib— uncovered
MYC_TARGETS_V10.530Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.510Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.490Inavolisib— uncovered
MTORC1_SIGNALING0.470Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.460Idelalisib— uncovered
COMPLEMENT0.430Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.360Remibrutinib— uncovered
UV_RESPONSE_UP0.340Idelalisib— uncovered
DNA_REPAIR0.320Idelalisib— uncovered
P53_PATHWAY0.300Idelalisib— uncovered
PANCREAS_BETA_CELLS0.300Cobimetinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.290Inavolisib— uncovered
APOPTOSIS0.270Idelalisib— uncovered
IL2_STAT5_SIGNALING0.260Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.240Inavolisib— uncovered