SJEPD033_D.RNA-Seq
EPN · Supratentorial EPN
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- EPN
- cancer_type_detailed
- —
- subtype
- Supratentorial EPN
- cancer_type
- EPN
- subtype
- Supratentorial EPN
- age_years
- 6.55
- fusion
- ZFTA_RELA
- e1_e2
- E1
- umap1_2d
- -2.936211811
- umap2_2d
- 0.247377835
- umap1_3d
- 1.1405029
- umap2_3d
- 3.752638126
- umap3_3d
- -2.651256984
- dataset
- EPN-StJude
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.490
- G2M_CHECKPOINT+0.490
- MYC_TARGETS_V2+0.400
- CHOLESTEROL_HOMEOSTASIS+0.270
- WNT_BETA_CATENIN_SIGNALING+0.260
- MITOTIC_SPINDLE+0.240
- PANCREAS_BETA_CELLS+0.240
- UNFOLDED_PROTEIN_RESPONSE+0.230
- MTORC1_SIGNALING+0.190
- MYC_TARGETS_V1+0.150
Top 10 suppressed
- UV_RESPONSE_DN-0.410
- OXIDATIVE_PHOSPHORYLATION-0.390
- IL6_JAK_STAT3_SIGNALING-0.330
- ALLOGRAFT_REJECTION-0.320
- TNFA_SIGNALING_VIA_NFKB-0.320
- INFLAMMATORY_RESPONSE-0.280
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.260
- IL2_STAT5_SIGNALING-0.260
- PROTEIN_SECRETION-0.230
- INTERFERON_GAMMA_RESPONSE-0.210
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2598228 | fetal | fetal | 0.806 |
| 2 | cfda240e-d071-418b-9a7d-a6fd30e60cdf | — | — | 0.796 |
| 3 | SJEPD036_D.RNA-Seq | EPN | Supratentorial EPN | 0.792 |
| 4 | ERR2598252 | fetal | fetal | 0.789 |
| 5 | s0094306 | — | — | 0.785 |
| 6 | BS_8SKZ7BRN | low-grade glioma | — | 0.775 |
| 7 | SRR17866833 | — | — | 0.775 |
| 8 | TCGA-E2-A109-01A-11R-A10J-07 | — | B | 0.768 |
| 9 | TCGA-56-7823-01B-11R-2247-07 | — | cohortSQ2 | 0.766 |
| 10 | A19ADC4B-C7E3-4855-9B59-009865D4FBF0 | — | — | 0.763 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 21 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.490 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.490 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.400 | Idelalisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.270 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.260 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.240 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.240 | Cobimetinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.230 | Idelalisib | — uncovered |
| MTORC1_SIGNALING | 0.190 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.150 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.130 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.130 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.110 | Temsirolimus | — uncovered |
| GLYCOLYSIS | 0.110 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.110 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.060 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.040 | Idelalisib | — uncovered |
| PEROXISOME | 0.030 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.010 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.010 | Inavolisib | — uncovered |