SRR13780267
— · cohortMD1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortMD1
- subtype
- cohortMD1
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.430
- G2M_CHECKPOINT+0.390
- MITOTIC_SPINDLE+0.350
- MYC_TARGETS_V1+0.340
- MYC_TARGETS_V2+0.260
- DNA_REPAIR+0.230
- GLYCOLYSIS+0.210
- UNFOLDED_PROTEIN_RESPONSE+0.150
- UV_RESPONSE_DN+0.080
- BILE_ACID_METABOLISM+0.040
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.470
- INFLAMMATORY_RESPONSE-0.470
- ANGIOGENESIS-0.440
- ALLOGRAFT_REJECTION-0.430
- INTERFERON_GAMMA_RESPONSE-0.430
- INTERFERON_ALPHA_RESPONSE-0.420
- TNFA_SIGNALING_VIA_NFKB-0.390
- COMPLEMENT-0.340
- APOPTOSIS-0.330
- PANCREAS_BETA_CELLS-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-66-2793-01A-01R-1201-07 | — | cohortMD1 | 0.920 |
| 2 | TCGA-33-4587-01A-11R-2125-07 | — | cohortMD1 | 0.915 |
| 3 | C3L-04013 | — | cohortMD1 | 0.908 |
| 4 | SJEPD030795_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.908 |
| 5 | TCGA-O2-A5IB-01A-11R-A27Q-07 | — | cohortMD1 | 0.904 |
| 6 | TCGA-43-6143-01A-11R-1820-07 | — | cohortMD1 | 0.901 |
| 7 | BS_53M8PP88 | EPN | EPN Tumor | 0.898 |
| 8 | MNG903 | — | — | 0.894 |
| 9 | SRR13780247 | — | cohortMD1 | 0.894 |
| 10 | MDT-AP-1234 | Med | Medulloblastoma | 0.890 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.430 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.390 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.350 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.340 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.260 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.230 | Idelalisib | — uncovered |
| GLYCOLYSIS | 0.210 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.150 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.080 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.040 | Inavolisib | — uncovered |
| PEROXISOME | 0.040 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.030 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.020 | Inavolisib | — uncovered |